DDR1 anticorps (AA 396-430)

N° du produit ABIN6243407

Cet anticorps Lapin Polyclonal détecte spécifiquement DDR1 dans WB. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour DDR1 anticorps (AA 396-430) (ABIN6243407)

Antigène: DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DDR1 est non-conjugé

Application: Western Blotting (WB)

Clone: RB50593

Détail du produit anti-DDR1 anticorps

Épitope: AA 396-430

Homologie: Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This Mouse Ddr1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 396-430 amino acids from the Central region of human Mouse Ddr1.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur DDR1

Antigène: DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Autre désignation: Ddr1

Sujet: Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing, but also tumor cell invasion. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Phosphorylates PTPN11 (By similarity). Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing.

Poids moléculaire: 101161

UniProt: Q03146

Pathways: Signalisation RTK, Smooth Muscle Cell Migration