SUFUH anticorps

N° du produit ABIN6244107

L’anticorps Souris Monoclonal anti-SUFUH a été validé pour WB et IHC (p). Il convient pour détecter SUFUH dans des échantillons de Humain, Souris et Green Monkey.

Aperçu rapide pour SUFUH anticorps (ABIN6244107)

Antigène: SUFUH (Suppressor of Fused Homolog (SUFUH))

Reactivité: Humain, Souris, Green Monkey

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SUFUH est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 1783CT536-263-29

Détail du produit anti-SUFUH anticorps

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogène: This SUFU antibody is generated from a mouse immunized with a recombinant protein of human SUFU.

Isotype: IgG1 kappa

Information d'application

Indications d'application: WB: 1:2000. IHC-P: 1:25

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur SUFUH

Antigène: SUFUH (Suppressor of Fused Homolog (SUFUH))

Autre désignation: SUFU

Sujet: Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU- GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A). Required for the proper formation of hair follicles and the control of epidermal differentiation (By similarity).

Poids moléculaire: 53947

UniProt: Q9UMX1

Pathways: Signalisation Hedgehog, Tube Formation, Maintenance of Protein Location