VCAM1 anticorps

N° du produit ABIN6253937

L’anticorps Souris Monoclonal anti-VCAM1 a été validé pour FACS et ICC. Il convient pour détecter VCAM1 dans des échantillons de Humain.

Aperçu rapide pour VCAM1 anticorps (ABIN6253937)

Antigène: VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp VCAM1 est non-conjugé

Application: Flow Cytometry (FACS), Immunocytochemistry (ICC)

Clone: B-K9

Détail du produit anti-VCAM1 anticorps

Specificité: B-K9 produces mouse IgG1 immunoglobulins directed against a 110 kD protein known as human CD106. It reacts with approximately 15% of peripheral lymphocytes and between 30-90% activated HUVEC

Pureté: PURE

Isotype: IgG1

Information d'application

Indications d'application: tochemistry on cytospots,  immunohistochemistry on frozen tissue sections

Restrictions: For Research Use only

Stockage

Format: Liquid

Stock: 4 °C

Détails sur VCAM1

Antigène: VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))

Autre désignation: CD106

Sujet: Antigen distribution: CD106 antigen binds the integrins a4b1 (CD49d/CD29, VLA-4) and a4b7 [4]. VLA-4 is the dominant ligand in cells expressing both integrins. Endothelial CD106 contributes to the extravasation of lymphocytes, monocytes, basophils and eosinophils (but not neutrophils) from blood vessels, especially at sites of inflammation. The VLA-4 interaction can mediate both the initial tethering and rolling of lymphocytes on endothelium as well as their subsequent arrest and firm adhesion [5]. CD106 expression on non-vascular tissues is thought to play a role in the interaction of hematopoietic progenitors with bone marrow stromal cells, B cell binding to follicular dendritic cells, co-stimulation of T cells and embryonic development [1,2,3]. Cellular Expression: VCAM-1. Vascular endothelium, dendritic cells, macrophages

Pathways: Carbohydrate Homeostasis