Histone 3 anticorps (H3S11ph)
Aperçu rapide pour Histone 3 anticorps (H3S11ph) (ABIN6254919)
Antigène
Voir toutes Histone 3 (H3) AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Épitope
- H3S11ph
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Fonction
- Phospho-Histone H3 (Ser11) Antibody
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Specificité
- Phospho-Histone H3.1 (Ser10) Antibody detects endogenous levels of Histone H3.1 only when phosphorylated at Serine 10
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Homologie
- Bovine
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Purification
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
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Immunogène
- A synthesized peptide derived from human Histone H3 around the phosphorylation site of Ser11.
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Isotype
- IgG
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Indications d'application
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 mg/mL
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Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Stock
- -20 °C
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Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
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Date de péremption
- 12 months
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: "Rictor regulates the vasculogenic mimicry of melanoma via the AKT-MMP-2/9 pathway." dans: Journal of cellular and molecular medicine, Vol. 21, Issue 12, pp. 3579-3591, (2018) (PubMed).
: "MAD2-p31comet axis deficiency reduces cell proliferation, migration and sensitivity of microtubule-interfering agents in glioma." dans: Biochemical and biophysical research communications, Vol. 498, Issue 1, pp. 157-163, (2018) (PubMed).
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- Histone 3 (H3) (Histone H3 (H3))
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Autre désignation
- Histone H3
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Sujet
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Description: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Gene: HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J
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Poids moléculaire
- 17kDa
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ID gène
- 8, 350, 835
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UniProt
- P68431
Antigène
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