Cyclin D2 anticorps (pThr280)

N° du produit ABIN6255653

Détail du produit anti-Cyclin D2 anticorps

Antigène: Cyclin D2 (CCND2)

Épitope: pThr280

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cyclin D2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: Phospho-Cyclin D2 (Thr280) Antibody detects endogenous levels of Cyclin D2 only when phosphorylated at Thr280.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogène: A synthesized peptide derived from human Cyclin D2 around the phosphorylation site of Thr280.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur Cyclin D2

Antigène: Cyclin D2 (CCND2)

Autre désignation: CCND2 (CCND2 Produits)

Synonymes: anticorps si:ch211-240j22.2, anticorps ccnd2, anticorps CCND2, anticorps kiak0002, anticorps zgc:162280, anticorps LOC100224096, anticorps KIAK0002, anticorps BF642806, anticorps C86853, anticorps Vin-1, anticorps Vin1, anticorps cD2, anticorps 2600016F06Rik, anticorps AI256817, anticorps cyclin D2, b, anticorps cyclin D2 S homeolog, anticorps cyclin D2, anticorps G1/S-specific cyclin-D2, anticorps cyclin D2, a, anticorps cyclin D2 L homeolog, anticorps ccnd2b, anticorps ccnd2.S, anticorps CCND2, anticorps ccnd2, anticorps ccnd2a, anticorps Ccnd2, anticorps ccnd2.L

Sujet:

Description: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).

Gene: CCND2

Poids moléculaire: 33 kDa

ID gène: 894

UniProt: P30279

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases