Cadherin 5 anticorps (pTyr731)

N° du produit ABIN6256011

L’anticorps Lapin Polyclonal anti-Cadherin 5 a été validé pour WB, IHC, ELISA, ICC et IF. Il convient pour détecter Cadherin 5 dans des échantillons de Humain et Souris.

Aperçu rapide pour Cadherin 5 anticorps (pTyr731) (ABIN6256011)

Antigène: Cadherin 5 (CDH5)

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cadherin 5 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Détail du produit anti-Cadherin 5 anticorps

Épitope: pTyr731

Specificité: Phospho-VE-Cadherin (Tyr731) Antibody detects endogenous levels of VE-Cadherin only when phosphorylated at Tyrosine 731.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Dog,Chicken

Purification: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogène: A synthesized peptide derived from human VE-Cadherin around the phosphorylation site of Tyr731.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur Cadherin 5

Antigène: Cadherin 5 (CDH5)

Autre désignation: CDH5

Sujet:

Description: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells, cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.

Gene: CDH5

Poids moléculaire: 130kDa

ID gène: 1003

UniProt: P33151

Pathways: Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2