RYR2 anticorps (pSer2814)

N° du produit ABIN6256236

L’anticorps anti-RYR2 Polyclonal Lapin est utilisé pour la détection de RYR2 dans des échantillons de Humain et Chien. Il a été validé pour IHC et WB.

Aperçu rapide pour RYR2 anticorps (pSer2814) (ABIN6256236)

Antigène: RYR2 (Ryanodine Receptor 2 (Cardiac) (RYR2))

Reactivité: Humain, Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RYR2 est non-conjugé

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Détail du produit anti-RYR2 anticorps

Épitope: pSer2814

Specificité: Phospho-RYR2( Ser2814) Antibody detects endogenous levels of RYR2.

Réactivité croisée: Chien, Humain

Purification: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogène: A synthesized peptide derived from human RYR2 around the phosphorylation site of Ser2814.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.Stable for 12 months from date of receipt

Date de péremption: 12 months

Détails sur RYR2

Antigène: RYR2 (Ryanodine Receptor 2 (Cardiac) (RYR2))

Autre désignation: RYR2

Sujet:

Description: Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca2+ levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.

Gene: RYR2

Poids moléculaire: 564 kDa

ID gène: 6262

UniProt: Q92736

Pathways: Myometrial Relaxation and Contraction