BMP10 anticorps (Internal Region)

N° du produit ABIN6256960

Cet anticorps anti-BMP10 est un anticorps Lapin Polyclonal détectant BMP10 dans WB, ELISA, ICC et IF. Adapté pour Humain.

Aperçu rapide pour BMP10 anticorps (Internal Region) (ABIN6256960)

Antigène: BMP10 (Bone Morphogenetic Protein 10 (BMP10))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BMP10 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Détail du produit anti-BMP10 anticorps

Épitope: Internal Region

Specificité: BMP10 Antibody detects endogenous levels of total BMP10.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human BMP10, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur BMP10

Antigène: BMP10 (Bone Morphogenetic Protein 10 (BMP10))

Autre désignation: BMP10

Sujet:

Description: Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.

Gene: BMP10

Poids moléculaire: 48 kDa

ID gène: 27302

UniProt: O95393

Pathways: Hormone Activity, Regulation of Muscle Cell Differentiation