Septin 2 anticorps (Internal Region)

N° du produit ABIN6257343

Détail du produit anti-Septin 2 anticorps

Antigène: Septin 2 (SEPT2)

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Septin 2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: SEPT2 Antibody detects endogenous levels of total SEPT2.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human SEPT2, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur Septin 2

Antigène: Septin 2 (SEPT2)

Autre désignation: SEPT2 (SEPT2 Produits)

Synonymes: anticorps DIFF6, anticorps NEDD5, anticorps Pnutl3, anticorps hNedd5, anticorps AW208991, anticorps Nedd-5, anticorps Nedd5, anticorps mKIAA0158, anticorps Vesp11, anticorps nedd5, anticorps wu:fb52g01, anticorps wu:fb99a01, anticorps Septin-2A, anticorps Septin-A, anticorps diff6, anticorps pnutl3, anticorps sept2, anticorps septa, anticorps xlsepta, anticorps SEPT2, anticorps Sep-02, anticorps Septin-2B, anticorps hnedd5, anticorps sept2-B, anticorps Septin-2, anticorps septin 2, anticorps septin 2 L homeolog, anticorps septin 2-like, anticorps COG1487; VapC; putative nucleic acid-binding protein; contains PIN domain, anticorps septin 2 S homeolog, anticorps SEPT2, anticorps Sept2, anticorps sept2, anticorps sept2.L, anticorps SEPT2L, anticorps sepT2, anticorps sept2.S

Sujet:

Description: Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.

Gene: 2-Sep

Poids moléculaire: 41 kDa

ID gène: 4735

UniProt: Q15019