TYRO3 anticorps (C-Term)

N° du produit ABIN6257478

L’anticorps Lapin Polyclonal anti-TYRO3 a été validé pour WB et ELISA. Il convient pour détecter TYRO3 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour TYRO3 anticorps (C-Term) (ABIN6257478)

Antigène: TYRO3 (TYRO3 Protein Tyrosine Kinase (TYRO3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TYRO3 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-TYRO3 anticorps

Épitope: C-Term

Specificité: TYRO3 Antibody detects endogenous levels of total TYRO3.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human TYRO3, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Date de péremption: 12 months

Détails sur TYRO3

Antigène: TYRO3 (TYRO3 Protein Tyrosine Kinase (TYRO3))

Autre désignation: TYRO3

Sujet:

Description: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Gene: TYRO3

Poids moléculaire: 97 kDa ,

ID gène: 7301

UniProt: Q06418

Pathways: Signalisation RTK