GNA13 anticorps (N-Term)

N° du produit ABIN6257750

Détail du produit anti-GNA13 anticorps

Antigène: GNA13 (Guanine Nucleotide Binding Protein (G Protein), alpha 13 (GNA13))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GNA13 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: GNA13 Antibody detects endogenous levels of total GNA13.

Homologie: Pig,Rabbit,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human GNA13, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Date de péremption: 12 months

Détails sur GNA13

Antigène: GNA13 (Guanine Nucleotide Binding Protein (G Protein), alpha 13 (GNA13))

Autre désignation: GNA13 (GNA13 Produits)

Synonymes: anticorps Galpha13, anticorps gna13, anticorps wu:fe25e05, anticorps zgc:112436, anticorps Gna13, anticorps fj64c01, anticorps wu:fj64c01, anticorps GNA13, anticorps G13, anticorps AU024132, anticorps AU043124, anticorps G protein subunit alpha 13, anticorps guanine nucleotide binding protein (G protein), alpha 13a, anticorps guanine nucleotide binding protein (G protein), alpha 13b, anticorps guanine nucleotide binding protein, alpha 13, anticorps Gna13, anticorps gna13a, anticorps gna13b, anticorps GNA13

Sujet:

Description: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333).

Gene: GNA13

Poids moléculaire: 44 kDa

ID gène: 10672

UniProt: Q14344

Pathways: CXCR4-mediated Signaling Events