COPS2 anticorps (Internal Region)

N° du produit ABIN6258029

Détail du produit anti-COPS2 anticorps

Antigène: COPS2 (COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis) (COPS2))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp COPS2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: COPS2 Antibody detects endogenous levels of total COPS2.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human COPS2, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur COPS2

Antigène: COPS2 (COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis) (COPS2))

Autre désignation: COPS2 (COPS2 Produits)

Synonymes: anticorps COPS2, anticorps ALIEN, anticorps CSN2, anticorps SGN2, anticorps TRIP15, anticorps wu:fc05f05, anticorps wu:fc06g10, anticorps wu:fc60f04, anticorps wu:fl94f12, anticorps zgc:86624, anticorps csn2, anticorps Tb03.48O8.600, anticorps Trip15, anticorps AI315723, anticorps C85265, anticorps Csn2, anticorps Sgn2, anticorps alien-like, anticorps ATCSN2, anticorps CONSTITUTIVE PHOTOMORPHOGENIC 12, anticorps COP12, anticorps FUSCA 12, anticorps T20P8.4, anticorps T20P8_4, anticorps COP9 signalosome subunit 2, anticorps COP9 signalosome subunit 2 L homeolog, anticorps COP9 signalosome complex subunit 2, anticorps COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis), anticorps proteasome family protein, anticorps COPS2, anticorps cops2, anticorps cops2.L, anticorps Tb927.3.2320, anticorps AOR_1_576084, anticorps PTRG_07106, anticorps LOC100283498, anticorps Cops2, anticorps csn-2, anticorps FUS12

Sujet:

Description: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.

Gene: COPS2

Poids moléculaire: 55 kDa

ID gène: 9318

UniProt: P61201

Pathways: Cycle Cellulaire