NEIL1 anticorps (Internal Region)
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- Antigène Voir toutes NEIL1 Anticorps
- NEIL1 (Endonuclease VIII-Like 1 (NEIL1))
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Épitope
- Internal Region
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp NEIL1 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificité
- NEIL1 Antibody detects endogenous levels of total NEIL1.
- Homologie
- Horse,Sheep
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human NEIL1, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product NEIL1 Anticorps primaire
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- Indications d'application
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- NEIL1 (Endonuclease VIII-Like 1 (NEIL1))
- Autre désignation
- NEIL1 (NEIL1 Produits)
- Synonymes
- anticorps FPG1, anticorps NEI1, anticorps hFPG1, anticorps 2810450N13Rik, anticorps Nei1, anticorps nei-like DNA glycosylase 1, anticorps nei like DNA glycosylase 1, anticorps nei endonuclease VIII-like 1 (E. coli), anticorps Neil1, anticorps NEIL1
- Sujet
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Description: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
Gene: NEIL1
- Poids moléculaire
- 44 kDa
- ID gène
- 79661
- UniProt
- Q96FI4
- Pathways
- Réparation de l'ADN
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