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RAD51C anticorps (Internal Region)

RAD51C Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6259171
  • Antigène Voir toutes RAD51C Anticorps
    RAD51C (DNA Repair Protein RAD51 Homolog 3 (RAD51C))
    Épitope
    • 10
    • 9
    • 8
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    Humain, Souris, Rat
    Hôte
    • 37
    • 6
    • 1
    Lapin
    Clonalité
    • 39
    • 5
    Polyclonal
    Conjugué
    • 27
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp RAD51C est non-conjugé
    Application
    • 34
    • 22
    • 11
    • 6
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    Rad51C Antibody detects endogenous levels of total Rad51C.
    Homologie
    Sheep
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human Rad51C, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product RAD51C Anticorps primaire
  • Indications d'application
    WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    RAD51C (DNA Repair Protein RAD51 Homolog 3 (RAD51C))
    Autre désignation
    RAD51C (RAD51C Produits)
    Synonymes
    anticorps RGD1563765, anticorps CG2412, anticorps Dm CG2412, anticorps Dmel\\CG2412, anticorps zgc:101596, anticorps RAD51C, anticorps Rad51c, anticorps ATRAD51C, anticorps F4L23.21, anticorps RAS associated with diabetes protein 51C, anticorps R51H3, anticorps Rad51l2, anticorps BROVCA3, anticorps FANCO, anticorps RAD51L2, anticorps RAD51 paralog C, anticorps Rad51 recombinase D, anticorps Rad51 DNA recombinase 3, anticorps RAD51C protein, anticorps RAD51 homolog C, anticorps RAS associated with diabetes protein 51C, anticorps RAD51C, anticorps Rad51c, anticorps Rad51D, anticorps rad51c
    Sujet

    Description: Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Part of the RAD21 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment, CX3 seems to act downstream of RAD51 recruitment, both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Involved in RAD51 foci formation in response to DNA damage suggesting an involvement in early stages of HR probably in the invasion step. Has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Participates in branch migration and HJ resolution and thus is important for processing HR intermediates late in the DNA repair process, the function may be linked to the CX3 complex. Part of a PALB2-scaffolded HR complex containing BRCA2 and which is thought to play a role in DNA repair by HR. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis.

    Gene: RAD51C

    Poids moléculaire
    50 kDa
    ID gène
    5889
    UniProt
    O43502
    Pathways
    Réparation de l'ADN
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