CALCOCO2 anticorps (Internal Region)

N° du produit ABIN6260408

Cet anticorps Lapin Polyclonal détecte spécifiquement CALCOCO2 dans WB, IF, IHC et ICC. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour CALCOCO2 anticorps (Internal Region) (ABIN6260408)

Antigène: CALCOCO2 (Calcium Binding and Coiled-Coil Domain 2 (CALCOCO2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CALCOCO2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Détail du produit anti-CALCOCO2 anticorps

Épitope: Internal Region

Specificité: CALCOCO2 Antibody detects endogenous levels of total CALCOCO2.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human CALCOCO2, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur CALCOCO2

Antigène: CALCOCO2 (Calcium Binding and Coiled-Coil Domain 2 (CALCOCO2))

Autre désignation: CALCOCO2

Sujet:

Description: Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994).

Gene: CALCOCO2

Poids moléculaire: 52 kDa

ID gène: 10241

UniProt: Q13137