ERO1LB anticorps (Internal Region)

N° du produit ABIN6261602

Détail du produit anti-ERO1LB anticorps

Antigène: ERO1LB (ERO1-Like beta (ERO1LB))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERO1LB est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: ERO1LB Antibody detects endogenous levels of total ERO1LB.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human ERO1LB, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur ERO1LB

Antigène: ERO1LB (ERO1-Like beta (ERO1LB))

Autre désignation: ERO1B (ERO1LB Produits)

Synonymes: anticorps RGD1563548, anticorps 1300013B24Rik, anticorps 1700065B09Rik, anticorps AI447560, anticorps ero1-beta, anticorps endoplasmic reticulum oxidoreductase 1 beta, anticorps ERO1-like beta (S. cerevisiae), anticorps Ero1b, anticorps ERO1B, anticorps Ero1lb

Sujet:

Description: Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50 % of P4HB reoxidation rate), as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (<10 %). Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. May be involved in oxidative proinsulin folding in pancreatic cells, hence may play a role in glucose homeostasis.

Gene: ERO1B

Poids moléculaire: 40~50 kDa

ID gène: 56605

UniProt: Q86YB8

Pathways: SARS-CoV-2 Protein Interactome