GRP78 anticorps

N° du produit ABIN6262100

Cet anticorps Lapin Polyclonal détecte spécifiquement GRP78 dans WB, ELISA, IHC, IF et ICC. Il présente une réactivité envers Humain, Rat, Souris et Singe et a été mentionné dans 4+ publications.

Aperçu rapide pour GRP78 anticorps (ABIN6262100)

Antigène: GRP78 (HSPA5) (Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5))

Reactivité: Humain, Rat, Souris, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRP78 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Détail du produit anti-GRP78 anticorps

Specificité: GRP78 Antibody detects endogenous levels of total GRP78

Réactivité croisée: Humain, Singe, Souris, Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human GRP78

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000,IHC 1:50-1:200,IF 1:100-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.Stable for 12 months from date of receipt

Date de péremption: 12 months

Références pour anticorps anti-GRP78 (ABIN6262100)

Tang, Peng, Huang, Xie, Chen, Shen, Gao, You, Xie, Chen: "Neoisoliquiritigenin Inhibits Tumor Progression by Targeting GRP78-β- catenin Signaling in Breast Cancer." dans: Current cancer drug targets, Vol. 18, Issue 4, pp. 390-399, (2018) (PubMed).

Tan, Li, Zhai, Liu, Li, Yokota, Zhang: "Effects of knee loading on obesity-related non-alcoholic fatty liver disease in an ovariectomized mouse model with high-fat diet." dans: Hepatology research : the official journal of the Japan Society of Hepatology, Vol. 48, Issue 10, pp. 839-849, (2018) (PubMed).

Liu, Shen, Wang, Liu, Zheng, Luo: "EndophilinA2 protects against angiotensin II-induced cardiac hypertrophy by inhibiting angiotensin II type 1 receptor trafficking in neonatal rat cardiomyocytes." dans: Journal of cellular biochemistry, (2018) (PubMed).

Li, Yang, Li, Liu, Wang, Guo, Tan, Gao, Zhao, Zhang, Gou, Yokota, Zhang: "Role of endoplasmic reticulum stress in disuse osteoporosis." dans: Bone, Vol. 97, pp. 2-14, (2017) (PubMed).

Détails sur GRP78

Antigène: GRP78 (HSPA5) (Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5))

Autre désignation: GRP78

Sujet:

Description: Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:1550958, PubMed:19538957). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity).

Gene: HSPA5

Poids moléculaire: 78 kDa

ID gène: 3309

UniProt: P11021

Pathways: Thyroid Hormone Synthesis, ER-Nucleus Signaling