HSPE1 anticorps (Internal Region)

N° du produit ABIN6262388

Détail du produit anti-HSPE1 anticorps

Antigène: HSPE1 (Heat Shock 10kDa Protein 1 (Chaperonin 10) (HSPE1))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HSPE1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: HSP10 Antibody detects endogenous levels of total HSP10.

Homologie: Pig,Zebrafish,Bovine,Horse,Rabbit,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human HSP10, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000, IHC: 1:50-1:200, IF/ICC: 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur HSPE1

Antigène: HSPE1 (Heat Shock 10kDa Protein 1 (Chaperonin 10) (HSPE1))

Autre désignation: HSPE1 (HSPE1 Produits)

Synonymes: anticorps CPN10, anticorps EPF, anticorps GROES, anticorps HSP10, anticorps groS, anticorps Cpn10, anticorps cpn10, anticorps zgc:86747, anticorps hspe1, anticorps MGC89647, anticorps HSPE1, anticorps MITOCHONDRIAL CHAPERONIN 10, anticorps T15D22.2, anticorps T15D22_2, anticorps chaperonin 10, anticorps Dmel\\CG11267, anticorps Hsp10, anticorps anon-WO0118547.175, anticorps hsp10, anticorps crpB, anticorps chpS, anticorps 10kDa, anticorps mt-cpn10, anticorps heat shock protein family E (Hsp10) member 1, anticorps molecular chaperone GroES, anticorps chaperonin 10 kDa, anticorps chaperonin, 10 kDa, anticorps chaperonin-10 kDa, anticorps heat shock protein family E member 1, anticorps heat shock 10 protein 1, anticorps heat shock protein family E (Hsp10) member 1 L homeolog, anticorps heat shock 10kDa protein 1 (chaperonin 10) pseudogene, anticorps 10 kd chaperonin, anticorps chaperonin 10, anticorps Hsp10p, anticorps co-chaperonin 10, mitochondrial, anticorps CG11267 gene product from transcript CG11267-RA, anticorps co-chaperonin GroES, anticorps mitochondrial heat shock protein Hsp10 (predicted), anticorps chaperonin GroS, anticorps Hsp10 10 kDa chaperonin GROES, anticorps mitochondrial heat shock protein Hsp10, anticorps heat shock protein 10, anticorps heat shock protein 1 (chaperonin 10), anticorps heat shock 10kDa protein 1 (chaperonin 10), anticorps HSPE1, anticorps groES, anticorps groES2, anticorps TP01_0190, anticorps Cag_1167, anticorps Bm1_56470, anticorps Hspe1, anticorps hspe1, anticorps hspe1.L, anticorps LOC452179, anticorps Cpn10, anticorps CPN10, anticorps HSP10, anticorps CG11267, anticorps hsp10, anticorps groS

Sujet:

Description: Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:7912672, PubMed:1346131, PubMed:11422376). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable).

Gene: HSPE1

Poids moléculaire: 10kDa

ID gène: 3336

UniProt: P61604

Pathways: Positive Regulation of Endopeptidase Activity