IL28B anticorps

N° du produit ABIN6262561

Détail du produit anti-IL28B anticorps

Antigène: IL28B (Interleukin 28B (Interferon, lambda 3) (IL28B))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL28B est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificité: IL28B Antibody detects endogenous levels of total IL28B

Réactivité croisée: Humain, Souris, Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human IL28B

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000 IHC 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.Stable for 12 months from date of receipt

Date de péremption: 12 months

Détails sur IL28B

Antigène: IL28B (Interleukin 28B (Interferon, lambda 3) (IL28B))

Autre désignation: IL28B (IL28B Produits)

Synonymes: anticorps Il28b, anticorps IFL-1, anticorps IL-28B, anticorps INF-alpha, anticorps INF-lambda, anticorps Il28, anticorps IL28B, anticorps IL28C, anticorps interferon, lambda 3, anticorps interferon lambda 3, anticorps Ifnl3, anticorps IFNL3

Sujet:

Description: Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.

Gene: IFNL3

Poids moléculaire: 22 kDa

ID gène: 282617

UniProt: Q8IZI9, Q8IZJ0