Integrin beta 4 anticorps (C-Term)

N° du produit ABIN6262617

L’anticorps Lapin Polyclonal anti-Integrin beta 4 a été validé pour WB, IHC, ELISA, IF et ICC. Il convient pour détecter Integrin beta 4 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Integrin beta 4 anticorps (C-Term) (ABIN6262617)

Antigène: Integrin beta 4 (ITGB4)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Integrin beta 4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Détail du produit anti-Integrin beta 4 anticorps

Épitope: C-Term

Specificité: Integrin beta 4 Antibody detects endogenous levels of total Integrin beta 4.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human Integrin beta 4, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur Integrin beta 4

Antigène: Integrin beta 4 (ITGB4)

Autre désignation: ITGB4

Sujet:

Description: Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464).

Gene: ITGB4

Poids moléculaire: 202 kDa

ID gène: 3691

UniProt: P16144

Pathways: Integrin Complex