MAD2L2 anticorps (Internal Region)

N° du produit ABIN6263049

L’anticorps Lapin Polyclonal anti-MAD2L2 a été validé pour WB, IF, IHC et ICC. Il convient pour détecter MAD2L2 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour MAD2L2 anticorps (Internal Region) (ABIN6263049)

Antigène: MAD2L2 (MAD2 Mitotic Arrest Deficient-Like 2 (MAD2L2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAD2L2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Détail du produit anti-MAD2L2 anticorps

Épitope: Internal Region

Specificité: MAD2L2 Antibody detects endogenous levels of total MAD2L2.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human MAD2L2, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur MAD2L2

Antigène: MAD2L2 (MAD2 Mitotic Arrest Deficient-Like 2 (MAD2L2))

Autre désignation: MAD2L2

Sujet:

Description: Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.

Gene: MAD2L2

Poids moléculaire: 24 kDa

ID gène: 10459

UniProt: Q9UI95