NEURL anticorps (Internal Region)

N° du produit ABIN6263606

Cet anticorps Lapin Polyclonal détecte spécifiquement NEURL dans WB, ELISA, IF et ICC. Il présente une réactivité envers Humain.

Aperçu rapide pour NEURL anticorps (Internal Region) (ABIN6263606)

Antigène: NEURL (Neuralized Homolog (Drosophila) (NEURL))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NEURL est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Détail du produit anti-NEURL anticorps

Épitope: Internal Region

Specificité: Neuralized-1 Antibody detects endogenous levels of total Neuralized-1.

Homologie: Pig,Bovine,Rabbit

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human Neuralized-1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur NEURL

Antigène: NEURL (Neuralized Homolog (Drosophila) (NEURL))

Autre désignation: NEURL1

Sujet:

Description: Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor, inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.

Gene: NEURL1

Poids moléculaire: 62kDa

ID gène: 9148

UniProt: O76050

Pathways: Signalisation Notch, EGFR Signaling Pathway