NEURL anticorps (Internal Region)

N° du produit ABIN6263606

Détail du produit anti-NEURL anticorps

Antigène: NEURL (Neuralized Homolog (Drosophila) (NEURL))

Épitope: Internal Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NEURL est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: Neuralized-1 Antibody detects endogenous levels of total Neuralized-1.

Homologie: Pig,Bovine,Rabbit

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human Neuralized-1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur NEURL

Antigène: NEURL (Neuralized Homolog (Drosophila) (NEURL))

Autre désignation: NEURL1 (NEURL Produits)

Synonymes: anticorps Xneur, anticorps neurl-A, anticorps zgc:153971, anticorps si:dkey-82d4.1, anticorps si:dkey-82d4.3, anticorps h-neu, anticorps rnf67, anticorps neurl1, anticorps neuralized, anticorps NEURL1, anticorps RNF67, anticorps bA416N2.1, anticorps neu, anticorps neu-1, anticorps 2410129E16Rik, anticorps AI450910, anticorps AI481072, anticorps Neu1, anticorps Neur1, anticorps Neurl, anticorps Nlz, anticorps Rnf67, anticorps Neurl1a, anticorps NEURL, anticorps neurlb, anticorps zgc:153175, anticorps neuralized E3 ubiquitin protein ligase 1 L homeolog, anticorps neuralized E3 ubiquitin protein ligase 1, anticorps neuralized E3 ubiquitin protein ligase 1Aa, anticorps neuralized E3 ubiquitin protein ligase 1A, anticorps neuralized E3 ubiquitin protein ligase 1Ab, anticorps neurl1.L, anticorps NEURL1, anticorps neurl1aa, anticorps neurl1, anticorps Neurl1a, anticorps Neurl1, anticorps neurl1ab

Sujet:

Description: Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor, inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.

Gene: NEURL1

Poids moléculaire: 62kDa

ID gène: 9148

UniProt: O76050

Pathways: Signalisation Notch, EGFR Signaling Pathway