NLRX1 anticorps (Internal Region)

N° du produit ABIN6263660

Détail du produit anti-NLRX1 anticorps

Antigène: NLRX1 (NLR Family Member X1 (NLRX1))

Épitope: Internal Region

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NLRX1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: NLRX1 Antibody detects endogenous levels of total NLRX1.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human NLRX1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur NLRX1

Antigène: NLRX1 (NLR Family Member X1 (NLRX1))

Autre désignation: NLRX1 (NLRX1 Produits)

Synonymes: anticorps CLR11.3, anticorps DLNB26, anticorps NOD26, anticorps NOD5, anticorps NOD9, anticorps BC034204, anticorps RGD1311293, anticorps NLR family member X1, anticorps NLRX1, anticorps nlrx1, anticorps Nlrx1

Sujet:

Description: Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 (PubMed:22749352). Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis (PubMed:27393910). Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313).

Gene: NLRX1

Poids moléculaire: 100-110 kDa

ID gène: 79671

UniProt: Q86UT6

Pathways: SARS-CoV-2 Protein Interactome