NOD2 anticorps (N-Term)

N° du produit ABIN6263679

Détail du produit anti-NOD2 anticorps

Antigène: NOD2 (Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NOD2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: NOD2 Antibody detects endogenous levels of total NOD2.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human NOD2, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur NOD2

Antigène: NOD2 (Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2))

Autre désignation: NOD2 (NOD2 Produits)

Synonymes: anticorps ACUG, anticorps BLAU, anticorps CARD15, anticorps CD, anticorps CLR16.3, anticorps IBD1, anticorps NLRC2, anticorps NOD2B, anticorps PSORAS1, anticorps Card15, anticorps F830032C23Rik, anticorps Nlrc2, anticorps caspase recruitment domain 15 protein, anticorps nucleotide binding oligomerization domain containing 2, anticorps nucleotide-binding oligomerization domain containing 2, anticorps TTHERM_01951320, anticorps NOD2, anticorps Nod2

Sujet:

Description: Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561). Component of an autophagy-mediated antibacterial pathway together with ATG16L1 (PubMed:20637199). Plays also a role in sensing single-stranded RNA (ssRNA) from viruses. Interacts with mitochondrial antiviral signaling/MAVS, leading to activation of interferon regulatory factor-3/IRF3 and expression of type I interferon (PubMed:19701189).

Gene: NOD2

Poids moléculaire: 100-110 kDa

ID gène: 64127

UniProt: Q9HC29

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome