Poly(A) Binding Protein, Cytoplasmic, Pseudogene 2 (PABPCP2) (C-Term) anticorps

N° du produit ABIN6264007

Cet anticorps anti-Poly(A) Binding Protein, Cytoplasmic, Pseudogene 2 Polyclonal Lapin (ABIN6264007) détecte spécifiquement Poly(A) Binding Protein, Cytoplasmic, Pseudogene 2 dans WB, IF, IHC et ICC. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Poly(A) Binding Protein, Cytoplasmic, Pseudogene 2 (PABPCP2) (C-Term) anticorps (ABIN6264007)

Antigène: Poly(A) Binding Protein, Cytoplasmic, Pseudogene 2 (PABPCP2)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Détail du produit

Épitope: C-Term

Fonction: PABP2 Antibody

Specificité: PABP2 Antibody detects endogenous levels of total PABP2.

Homologie: Pig,Bovine,Horse,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human PABP2, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, IF/ICC 1:100-1:500, IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détail du antigène

Antigène: Poly(A) Binding Protein, Cytoplasmic, Pseudogene 2 (PABPCP2)

Autre désignation: PABP2

Sujet:

Description: Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes (PubMed:11371506). Binds to poly(A) and to poly(G) with high affinity (By similarity). May protect the poly(A) tail from degradation (By similarity). Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484).

Gene: PABPN1

Poids moléculaire: 49 kDa

ID gène: 8106

UniProt: Q86U42