PDIA6 anticorps (C-Term)

N° du produit ABIN6264114

L’anticorps Lapin Polyclonal anti-PDIA6 a été validé pour WB, IHC, IF et ICC. Il convient pour détecter PDIA6 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour PDIA6 anticorps (C-Term) (ABIN6264114)

Antigène: PDIA6 (Protein Disulfide Isomerase Family A, Member 6 (PDIA6))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PDIA6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Détail du produit anti-PDIA6 anticorps

Épitope: C-Term

Specificité: PDIA6 Antibody detects endogenous levels of total PDIA6.

Homologie: Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human PDIA6, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur PDIA6

Antigène: PDIA6 (Protein Disulfide Isomerase Family A, Member 6 (PDIA6))

Autre désignation: PDIA6

Sujet:

Description: May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936).

Gene: PDIA6

Poids moléculaire: 54 kDa

ID gène: 10130

UniProt: Q15084

Pathways: ER-Nucleus Signaling, Cell RedoxHomeostasis