CD31 anticorps (C-Term)

N° du produit ABIN6264129

L’anticorps Lapin Polyclonal anti-CD31 a été validé pour WB, IHC, IF, ELISA et ICC. Il convient pour détecter CD31 dans des échantillons de Humain, Souris et Rat. Il y a 3+ publications disponibles.

Aperçu rapide pour CD31 anticorps (C-Term) (ABIN6264129)

Antigène: CD31 (PECAM1) (Platelet/endothelial Cell Adhesion Molecule (PECAM1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CD31 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA, Immunocytochemistry (ICC)

Détail du produit anti-CD31 anticorps

Épitope: C-Term

Specificité: CD31 Antibody detects endogenous levels of total CD31.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human CD31, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl and glycerol.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Références pour anticorps anti-CD31 (ABIN6264129)

Liu, Huang, Jin, Zhou, Chen, Li, Chen, Li, Yao, Li, Lan, Ye, Wang: "MicroRNA-370 inhibits the growth and metastasis of lung cancer by down-regulating epidermal growth factor receptor expression." dans: Oncotarget, Vol. 8, Issue 50, pp. 88139-88151, (2018) (PubMed).

Li, Chen, Wang, Wang, Liu: "Calpain inhibition improves erectile function in diabetic mice via upregulating endothelial nitric oxide synthase expression and reducing apoptosis." dans: Asian journal of andrology, Vol. 20, Issue 4, pp. 342-348, (2018) (PubMed).

Song, Hai, Wang, Zhao, Chen, Cui, Xie, Yu, Li, Wu, Li: "Realgar transforming solution suppresses angiogenesis and tumor growth by inhibiting VEGF receptor 2 signaling in vein endothelial cells." dans: Archives of pharmacal research, Vol. 41, Issue 4, pp. 467-480, (2018) (PubMed).

Détails sur CD31

Antigène: CD31 (PECAM1) (Platelet/endothelial Cell Adhesion Molecule (PECAM1))

Autre désignation: PECAM1

Sujet:

Description: Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:19342684, PubMed:17580308). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells, PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896). Induces susceptibility to atherosclerosis (By similarity).

Gene: PECAM1

Poids moléculaire: 82kDa

ID gène: 5175

UniProt: P16284

Pathways: Regulation of Actin Filament Polymerization