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PTTG1 anticorps (Internal Region)

PTTG1 Reactivité: Humain WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6264528
  • Antigène Voir toutes PTTG1 Anticorps
    PTTG1 (Pituitary Tumor-Transforming 1 (PTTG1))
    Épitope
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 47
    • 12
    • 11
    • 1
    Humain
    Hôte
    • 36
    • 11
    • 1
    Lapin
    Clonalité
    • 30
    • 18
    Polyclonal
    Conjugué
    • 30
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp PTTG1 est non-conjugé
    Application
    • 23
    • 18
    • 12
    • 9
    • 8
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    PTTG1 Antibody detects endogenous levels of total PTTG1.
    Homologie
    Pig,Bovine,Sheep,Rabbit,Dog
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human PTTG1, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product PTTG1 Anticorps primaire
  • Indications d'application
    WB: 1:500-1:3000, IF/ICC: 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    PTTG1 (Pituitary Tumor-Transforming 1 (PTTG1))
    Autre désignation
    PTTG1 (PTTG1 Produits)
    Synonymes
    anticorps EAP1, anticorps HPTTG, anticorps PTTG, anticorps TUTR1, anticorps PTTG1, anticorps securin, anticorps AW555095, anticorps C87862, anticorps Pttg, anticorps Pttg3, anticorps Securin, anticorps Protein Cut2, anticorps pituitary tumor-transforming 1, anticorps pituitary tumor-transforming gene 1, anticorps securin, sister chromatid separation inhibitor, anticorps PTTG1, anticorps Pttg1, anticorps cut2
    Sujet

    Description: Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.

    Gene: PTTG1

    Poids moléculaire
    30kDa
    ID gène
    9232
    UniProt
    O95997
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