ARHGAP24 anticorps (Internal Region)

N° du produit ABIN6264735

Détail du produit anti-ARHGAP24 anticorps

Antigène: ARHGAP24 (rho GTPase Activating Protein 24 (ARHGAP24))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ARHGAP24 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificité: RHG24 Antibody detects endogenous levels of total RHG24.

Homologie: Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human RHG24, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur ARHGAP24

Antigène: ARHGAP24 (rho GTPase Activating Protein 24 (ARHGAP24))

Autre désignation: ARHGAP24 (ARHGAP24 Produits)

Synonymes: anticorps FILGAP, anticorps RC-GAP72, anticorps RCGAP72, anticorps p73, anticorps p73RhoGAP, anticorps 0610025G21Rik, anticorps si:ch211-65i12.2, anticorps Rho GTPase activating protein 24, anticorps ARHGAP24, anticorps Arhgap24, anticorps arhgap24

Sujet:

Description: Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.

Gene: ARHGAP24

Poids moléculaire: 84 kDa

ID gène: 83478

UniProt: Q8N264

Pathways: Regulation of Cell Size, Positive Regulation of Response to DNA Damage Stimulus