SENP6 anticorps (Internal Region)

N° du produit ABIN6264987

L’anticorps Lapin Polyclonal anti-SENP6 a été validé pour ELISA, IHC et WB. Il convient pour détecter SENP6 dans des échantillons de Humain et Souris.

Aperçu rapide pour SENP6 anticorps (Internal Region) (ABIN6264987)

Antigène: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SENP6 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Western Blotting (WB)

Détail du produit anti-SENP6 anticorps

Épitope: Internal Region

Specificité: SENP6 Antibody detects endogenous levels of total SENP6.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human SENP6, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: IHC 1:50-1:200, WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur SENP6

Antigène: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Autre désignation: SENP6

Sujet:

Description: Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.

Gene: SENP6

Poids moléculaire: 126kDa

ID gène: 26054

UniProt: Q9GZR1