SOCS3 anticorps (C-Term)

N° du produit ABIN6265217

Détail du produit anti-SOCS3 anticorps

Antigène: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SOCS3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Specificité: SOCS3 Antibody detects endogenous levels of total SOCS3.

Homologie: Bovine,Horse,Sheep,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human SOCS3, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur SOCS3

Antigène: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Autre désignation: SOCS3 (SOCS3 Produits)

Synonymes: anticorps socs3, anticorps fj09e12, anticorps zgc:56537, anticorps wu:fj09e12, anticorps MGC64393, anticorps MGC75749, anticorps xsocs3, anticorps MGC81248, anticorps atod4, anticorps cis3, anticorps cish3, anticorps socs-3, anticorps ssi-3, anticorps ssi3, anticorps SOCS3, anticorps ATOD4, anticorps CIS3, anticorps Cish3, anticorps SOCS-3, anticorps SSI-3, anticorps SSI3, anticorps Cis3, anticorps EF-10, anticorps Ef10, anticorps Ssi3, anticorps Socs-3, anticorps Ssi-3, anticorps suppressor of cytokine signaling 3a, anticorps suppressor of cytokine signaling 3 S homeolog, anticorps suppressor of cytokine signaling 3, anticorps suppressor of cytokine signaling 3 L homeolog, anticorps socs3a, anticorps socs3.S, anticorps socs3, anticorps socs3.L, anticorps SOCS3, anticorps Socs3

Sujet:

Description: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).

Gene: SOCS3

Poids moléculaire: 25kDa

ID gène: 9021

UniProt: O14543

Pathways: Signalistation JAK/STAT, Response to Growth Hormone Stimulus, Hepatitis C