TBC1D23 anticorps (Internal Region)

N° du produit ABIN6265479

Détail du produit anti-TBC1D23 anticorps

Antigène: TBC1D23 (TBC1 Domain Family, Member 23 (TBC1D23))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TBC1D23 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: TBC1D23 Antibody detects endogenous levels of total TBC1D23.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human TBC1D23, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur TBC1D23

Antigène: TBC1D23 (TBC1 Domain Family, Member 23 (TBC1D23))

Autre désignation: TBC1D23 (TBC1D23 Produits)

Synonymes: anticorps RGD1307925, anticorps NS4ATP1, anticorps 4930451A13Rik, anticorps AU015720, anticorps AU043671, anticorps AU043778, anticorps D030022P07Rik, anticorps W51689, anticorps zgc:63756, anticorps TBC1 domain family, member 23, anticorps TBC1 domain family member 23, anticorps Tbc1d23, anticorps TBC1D23, anticorps tbc1d23

Sujet:

Description: Putative Rab GTPase-activating protein which plays a role in vesicular trafficking (PubMed:28823707). Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197). Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth (By similarity). May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (By similarity).

Gene: TBC1D23

Poids moléculaire: 78 kDa

ID gène: 55773

UniProt: Q9NUY8