TBC1D23 anticorps (AA 525-575)

N° du produit ABIN7452842

Détail du produit anti-TBC1D23 anticorps

Antigène: TBC1D23 (TBC1 Domain Family, Member 23 (TBC1D23))

Épitope: AA 525-575

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TBC1D23 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Fonction: Rabbit anti-TBC1D23 Antibody, Affinity Purified

Homologie: Mouse,Zebrafish,X. laevis,Chicken,Orangutan

Purification: Affinity Purified

Immunogène: between AA 525 and 575

Isotype: IgG

Information d'application

Indications d'application:

IP: 50-100 μL/mg lysate

WB: 1:10,000 - 1:25,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur TBC1D23

Antigène: TBC1D23 (TBC1 Domain Family, Member 23 (TBC1D23))

Autre désignation: TBC1D23 (TBC1D23 Produits)

Synonymes: anticorps RGD1307925, anticorps NS4ATP1, anticorps 4930451A13Rik, anticorps AU015720, anticorps AU043671, anticorps AU043778, anticorps D030022P07Rik, anticorps W51689, anticorps zgc:63756, anticorps TBC1 domain family, member 23, anticorps TBC1 domain family member 23, anticorps Tbc1d23, anticorps TBC1D23, anticorps tbc1d23

Sujet: Background: TBC1D23 is a putative Rab GTPase-activating protein which plays a role in vesicular trafficking and is involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles. Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1. TBC1D23 also plays a role in brain development, including in cortical neuron positioning. May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth. May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge. [taken from the Universal Protein Resource (UniProt) Q9NUY8].

ID gène: 55773

UniProt: Q9NUY8