PAR1 anticorps (N-Term)

N° du produit ABIN6265563

L’anticorps Lapin Polyclonal anti-PAR1 a été validé pour WB, ELISA, IHC, ICC et IF. Il convient pour détecter PAR1 dans des échantillons de Humain, Rat et Souris. Il y a 2+ publications disponibles.

Aperçu rapide pour PAR1 anticorps (N-Term) (ABIN6265563)

Antigène: PAR1 (F2R) (Coagulation Factor II (thrombin) Receptor (F2R))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PAR1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Détail du produit anti-PAR1 anticorps

Épitope: N-Term

Specificité: Thrombin Receptor Antibody detects endogenous levels of total Thrombin Receptor.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human Thrombin Receptor, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Références pour anticorps anti-PAR1 (ABIN6265563)

Zhao, Zheng, Liu, Luo, Wu, Liu, Zou: "Inhibiting trophoblast PAR-1 overexpression suppresses sFlt-1-induced anti-angiogenesis and abnormal vascular remodeling: a possible therapeutic approach for preeclampsia." dans: Molecular human reproduction, Vol. 24, Issue 3, pp. 158-169, (2018) (PubMed).

Zhong, Chen, Zhang, Xiao, Qin, Gu, Sun, Liu, Jing, Hu, Zhang, Zhou, Sun, Yang: "Doxycycline directly targets PAR1 to suppress tumor progression." dans: Oncotarget, Vol. 8, Issue 10, pp. 16829-16842, (2017) (PubMed).

Détails sur PAR1

Antigène: PAR1 (F2R) (Coagulation Factor II (thrombin) Receptor (F2R))

Autre désignation: F2R

Sujet:

Description: High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.

Gene: F2R

Poids moléculaire: 48kDa

ID gène: 2149

UniProt: P25116

Pathways: Nuclear Receptor Transcription Pathway, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus