TIMELESS anticorps (C-Term)
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- Antigène Voir toutes TIMELESS Anticorps
- TIMELESS (Timeless Homolog (TIMELESS))
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Épitope
- C-Term
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp TIMELESS est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Specificité
- TIMELESS Antibody detects endogenous levels of total TIMELESS.
- Homologie
- Pig
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human TIMELESS, corresponding to a region within C-terminal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product TIMELESS Anticorps primaire
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- Indications d'application
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- TIMELESS (Timeless Homolog (TIMELESS))
- Autre désignation
- TIMELESS (TIMELESS Produits)
- Synonymes
- anticorps TIM, anticorps TIM1, anticorps hTIM, anticorps C77407, anticorps Debt69, anticorps tim, anticorps CG3234, anticorps Dmel\\CG3234, anticorps Ritsu, anticorps Tim, anticorps dTIM, anticorps dTim, anticorps dtim, anticorps mel_tim, anticorps rit, anticorps tim1, anticorps XTimeless1, anticorps timeless, anticorps timelessb, anticorps TIMELESS, anticorps MXC20.14, anticorps MXC20_14, anticorps htim, anticorps im:6903167, anticorps wu:fa95g04, anticorps wu:fd23d07, anticorps timeless circadian regulator, anticorps timeless circadian clock 1, anticorps timeless, anticorps timeless circadian clock, anticorps timeless circadian clock S homeolog, anticorps timeless family protein, anticorps TIMELESS, anticorps Timeless, anticorps tim, anticorps timeless.S, anticorps Tim, anticorps ATIM, anticorps timeless, anticorps LOC100328917
- Sujet
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Description: Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication and in the regulation of the circadian clock. Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock. Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Forms a complex with TIPIN and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. Timeless promotes TIPIN nuclear localization. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.
Gene: TIMELESS
- Poids moléculaire
- 139 kDa
- ID gène
- 8914
- UniProt
- Q9UNS1
- Pathways
- Protein targeting to Nucleus, Photoperiodism
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