TOPBP1 anticorps (Internal Region)

N° du produit ABIN6265675

Cet anticorps anti-TOPBP1 est un anticorps Lapin Polyclonal détectant TOPBP1 dans WB et ELISA. Adapté pour Humain et Souris.

Aperçu rapide pour TOPBP1 anticorps (Internal Region) (ABIN6265675)

Antigène: TOPBP1 (Topoisomerase (DNA) II Binding Protein 1 (TOPBP1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TOPBP1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-TOPBP1 anticorps

Épitope: Internal Region

Specificité: TOPBP1 Antibody detects endogenous levels of total TOPBP1.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human TOPBP1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur TOPBP1

Antigène: TOPBP1 (Topoisomerase (DNA) II Binding Protein 1 (TOPBP1))

Autre désignation: TOPBP1

Sujet:

Description: Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR (PubMed:16530042).

Gene: TOPBP1

Poids moléculaire: 173kDa

ID gène: 11073

UniProt: Q92547

Pathways: Chromatin Binding