TOPBP1 anticorps (AA 1253-1522)

N° du produit ABIN7150350

Détail du produit anti-TOPBP1 anticorps

Antigène: TOPBP1 (Topoisomerase (DNA) II Binding Protein 1 (TOPBP1))

Épitope: AA 1253-1522

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TOPBP1 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human DNA topoisomerase 2-binding protein 1 protein (1253-1522AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur TOPBP1

Antigène: TOPBP1 (Topoisomerase (DNA) II Binding Protein 1 (TOPBP1))

Autre désignation: TOPBP1 (TOPBP1 Produits)

Synonymes: anticorps RGD1562949, anticorps TOPBP1, anticorps cut5, anticorps F2P24.3, anticorps F2P24_3, anticorps meiosis defective 1, anticorps TOP2BP1, anticorps 1110031N14Rik, anticorps 2810429C13Rik, anticorps AI256758, anticorps D430026L04Rik, anticorps mKIAA0259, anticorps TopBP1-A, anticorps TopBP1-B, anticorps Xmus101, anticorps XtopBP, anticorps mus101, anticorps top2bp1, anticorps DNA topoisomerase II binding protein 1, anticorps topoisomerase (DNA) II binding protein 1, anticorps dna topoisomerase ii binding protein 1 (IC), anticorps transcription coactivator, anticorps DNA topoisomerase II binding protein 1 L homeolog, anticorps Topbp1, anticorps topbp1, anticorps TOPBP1, anticorps MEI1, anticorps topbp1.L

Sujet:

Background: Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.

Aliases: DNA topoisomerase 2 binding protein 1 antibody, DNA topoisomerase 2-binding protein 1 antibody, DNA topoisomerase II binding protein 1 antibody, DNA topoisomerase II binding protein antibody, DNA topoisomerase II-beta-binding protein 1 antibody, DNA topoisomerase II-binding protein 1 antibody, DNA topoisomerase IIbeta binding protein 1 antibody, Hypothetical protein KIAA0259 [Fragment] antibody, KIAA0259 antibody, TOP2BP1 antibody, TOPB1_HUMAN antibody, TOPBP 1 antibody, TopBP1 antibody, Topoisomerase (DNA) II binding protein 1 antibody, Topoisomerase II binding protein 1 antibody

UniProt: Q92547

Pathways: Chromatin Binding