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TOPBP1 anticorps (Internal Region)

TOPBP1 Reactivité: Humain, Souris WB, ELISA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6265675
  • Antigène Voir toutes TOPBP1 Anticorps
    TOPBP1 (Topoisomerase (DNA) II Binding Protein 1 (TOPBP1))
    Épitope
    • 14
    • 12
    • 7
    • 6
    • 6
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 51
    • 14
    • 10
    Humain, Souris
    Hôte
    • 48
    • 4
    • 2
    Lapin
    Clonalité
    • 51
    • 3
    Polyclonal
    Conjugué
    • 27
    • 5
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp TOPBP1 est non-conjugé
    Application
    • 29
    • 27
    • 15
    • 9
    • 4
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA
    Specificité
    TOPBP1 Antibody detects endogenous levels of total TOPBP1.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human TOPBP1, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product TOPBP1 Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    TOPBP1 (Topoisomerase (DNA) II Binding Protein 1 (TOPBP1))
    Autre désignation
    TOPBP1 (TOPBP1 Produits)
    Synonymes
    anticorps RGD1562949, anticorps TOPBP1, anticorps cut5, anticorps F2P24.3, anticorps F2P24_3, anticorps meiosis defective 1, anticorps TOP2BP1, anticorps 1110031N14Rik, anticorps 2810429C13Rik, anticorps AI256758, anticorps D430026L04Rik, anticorps mKIAA0259, anticorps TopBP1-A, anticorps TopBP1-B, anticorps Xmus101, anticorps XtopBP, anticorps mus101, anticorps top2bp1, anticorps DNA topoisomerase II binding protein 1, anticorps topoisomerase (DNA) II binding protein 1, anticorps dna topoisomerase ii binding protein 1 (IC), anticorps transcription coactivator, anticorps DNA topoisomerase II binding protein 1 L homeolog, anticorps Topbp1, anticorps topbp1, anticorps TOPBP1, anticorps MEI1, anticorps topbp1.L
    Sujet

    Description: Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR (PubMed:16530042).

    Gene: TOPBP1

    Poids moléculaire
    173kDa
    ID gène
    11073
    UniProt
    Q92547
    Pathways
    Chromatin Binding
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