WWP1 anticorps (Internal Region)

N° du produit ABIN6266055

Détail du produit anti-WWP1 anticorps

Antigène: WWP1 (WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp WWP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: WWP1 Antibody detects endogenous levels of total WWP1.

Homologie: Pig,Zebrafish,Bovine,Horse,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human WWP1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur WWP1

Antigène: WWP1 (WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1))

Autre désignation: WWP1 (WWP1 Produits)

Synonymes: anticorps AIP5, anticorps Tiul1, anticorps hSDRP1, anticorps 8030445B08Rik, anticorps SDRP1, anticorps WWP1, anticorps aip5, anticorps tiul1, anticorps hsdrp1, anticorps WW domain containing E3 ubiquitin protein ligase 1, anticorps WWP1, anticorps Wwp1, anticorps wwp1

Sujet:

Description: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1, the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.

Gene: WWP1

Poids moléculaire: 95 kDa

ID gène: 11059

UniProt: Q9H0M0