GLRA1 anticorps (Internal Region)

N° du produit ABIN6266217

Détail du produit anti-GLRA1 anticorps

Antigène: GLRA1 (Glycine Receptor, alpha 1 (GLRA1))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GLRA1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: GLRA1 Antibody detects endogenous levels of total GLRA1.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human GLRA1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:100, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur GLRA1

Antigène: GLRA1 (Glycine Receptor, alpha 1 (GLRA1))

Autre désignation: GLRA1 (GLRA1 Produits)

Synonymes: anticorps GLYRA1, anticorps HKPX1, anticorps STHE, anticorps [a]Z1, anticorps B230397M16Rik, anticorps nmf11, anticorps oscillator, anticorps ot, anticorps spasmodic, anticorps spd, anticorps glycine receptor alpha 1, anticorps glycine receptor, alpha 1, anticorps glycine receptor, alpha 1 subunit, anticorps GLRA1, anticorps Glra1, anticorps glra1

Sujet:

Description: Glycine receptors are ligand-gated chloride channels (PubMed:23994010, PubMed:25730860). Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:7920629, PubMed:14551753, PubMed:16144831, PubMed:22715885, PubMed:22973015, PubMed:25973519, PubMed:9009272). Channel opening is also triggered by taurine and beta-alanine (PubMed:16144831, PubMed:9009272). Channel characteristics depend on the subunit composition, heteropentameric channels are activated by lower glycine levels and display faster desensitization (PubMed:14551753). Plays an important role in the down-regulation of neuronal excitability (PubMed:8298642, PubMed:9009272). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). Channel activity is potentiated by ethanol (PubMed:25973519). Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity).

Gene: GLRA1

Poids moléculaire: 53kDa

ID gène: 2741

UniProt: P23415

Pathways: Synaptic Membrane