TOX3 anticorps (AA 200-400)

N° du produit ABIN6294379

Cet anticorps Souris Monoclonal détecte spécifiquement TOX3 dans IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour TOX3 anticorps (AA 200-400) (ABIN6294379)

Antigène: TOX3 (TOX High Mobility Group Box Family Member 3 (TOX3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TOX3 est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-TOX3 anticorps

Épitope: AA 200-400

Fonction: Mouse anti-Human TOX-3 Antibody [IHC only]

Specificité: Cytoplasmic & nuclear

Purification: A recombinant fragment (139 amino acid residues around aa 200-400) from the human protein was used as the immunogen for the TOX-3 antibody.

Immunogène: A recombinant fragment (139 amino acid residues around aa 200-400) from the human protein was used as the immunogen for the TOX-3 antibody.

Information d'application

Indications d'application: Prediluted format : incubate for 30 min at RT (2)

Restrictions: For Research Use only

Stockage

Buffer: Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Détails sur TOX3

Antigène: TOX3 (TOX High Mobility Group Box Family Member 3 (TOX3))

Autre désignation: TOX high mobility group box family member 3

Sujet:

Target Description: It recognizes an ~63 kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2+-dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts.

Gene Symbol: TOX3///CAGF9///TNRC9

ID gène: 27324

UniProt: O15405

Pathways: Chromatin Binding