TOX3 anticorps (AA 200-400)

N° du produit ABIN6294382

Cet anticorps Souris Monoclonal détecte spécifiquement TOX3 dans FACS, IF et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour TOX3 anticorps (AA 200-400) (ABIN6294382)

Antigène: TOX3 (TOX High Mobility Group Box Family Member 3 (TOX3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TOX3 est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC)

Détail du produit anti-TOX3 anticorps

Épitope: AA 200-400

Fonction: Mouse anti-Human TOX3 Antibody [Sodium Azide Free]

Specificité: Cytoplasmic & nuclear

Purification: A recombinant fragment (139 amino acid residues around aa 200-400) from the human protein was used as the immunogen for the TOX3 antibody.

Immunogène: A recombinant fragment (139 amino acid residues around aa 200-400) from the human protein was used as the immunogen for the TOX3 antibody.

Information d'application

Indications d'application: Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 0.5-1 μg/mL
Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT (1)
Prediluted format: incubate for 30 min at RT (2)

Restrictions: For Research Use only

Stockage

Buffer: In 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Détails sur TOX3

Antigène: TOX3 (TOX High Mobility Group Box Family Member 3 (TOX3))

Autre désignation: TOX high mobility group box family member 3

Sujet:

Target Description: It recognizes a 63 kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2+-dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts.

Gene Symbol: TOX3///CAGF9///TNRC9

ID gène: 27324

UniProt: O15405

Pathways: Chromatin Binding