NUMA1 anticorps

N° du produit ABIN6296230

Cet anticorps Souris Monoclonal détecte spécifiquement NUMA1 dans WB, IHC et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour NUMA1 anticorps (ABIN6296230)

Antigène: NUMA1 (Nuclear Mitotic Apparatus Protein 1 (NUMA1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NUMA1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-NUMA1 anticorps

Fonction: Mouse anti-Human NuMA Antibody [Sodium Azide Free]

Specificité: Nuclear

Purification: Colon carcinoma 174T cells were used as the immunogen for the NuMA antibody.

Immunogène: Colon carcinoma 174T cells were used as the immunogen for the NuMA antibody.

Information d'application

Indications d'application: Western blot: 1-2 μg/mL
Immunofluorescence: 0.5-1 μg/mL
Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT (1)

Restrictions: For Research Use only

Stockage

Buffer: In 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Détails sur NUMA1

Antigène: NUMA1 (Nuclear Mitotic Apparatus Protein 1 (NUMA1))

Autre désignation: Nuclear mitotic apparatus protein 1

Sujet:

Target Description: Recognizes a phosphorylated protein of 228 kDa, identified as nuclear mitotic apparatus protein (NuMA). Its epitope is resistant to phosphatases. NuMA is intra-nuclear protein and present in nucleus during interphase. At the onset of mitosis, it redistributes from the nucleus to two centrosomal structures that later will become part of the mitotic spindle pole. After anaphase, the protein redistributes from the spindle polar region into reforming nucleus. NuMA is an essential protein during mitosis for the terminal phases of chromosome separation and/or nuclear reassembly. Recently a study shows that NuMA is cleaved to a 180 to 200 kDa during apoptosis. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 has been detected in patients with acute promyelocytic leukemia.

Gene Symbol: NUMA1///NMP22///NUMA

ID gène: 4926

UniProt: Q14980

Pathways: Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization, M Phase