FOXP3 anticorps

N° du produit ABIN6296306

L’anticorps Souris Monoclonal anti-FOXP3 a été validé pour FACS et IF. Il convient pour détecter FOXP3 dans des échantillons de Humain, Souris et Singe.

Aperçu rapide pour FOXP3 anticorps (ABIN6296306)

Antigène: FOXP3 (Forkhead Box P3 (FOXP3))

Reactivité: Humain, Souris, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FOXP3 est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Détail du produit anti-FOXP3 anticorps

Fonction: Mouse anti-Human/Monkey/Mouse FOXP3 Antibody [Sodium Azide Free]

Specificité: Predominantly nuclear, some cytoplasmic

Purification: Full-length His-tagged mouse FOXP3 protein was used as the immunogen for this FOXP3 antibody.

Immunogène: Full-length His-tagged mouse FOXP3 protein was used as the immunogen for this FOXP3 antibody.

Information d'application

Indications d'application: Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence (0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: In 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Détails sur FOXP3

Antigène: FOXP3 (Forkhead Box P3 (FOXP3))

Autre désignation: Forkhead box protein P3

Sujet:

Target Description: Recognizes a protein of 47-55 kDa, which is identified as FOXP3. Its precise epitope is not known, but it has been mapped to the N-terminal portion (amino acids 2-136) of the protein.The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung, with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. Mutations in FOXP3 gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T cell activation.

Gene Symbol: FOXP3///IPEX///JM2

ID gène: 50943

UniProt: Q9BZS1

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation