C4A anticorps

N° du produit ABIN6296522

Détail du produit anti-C4A anticorps

Antigène: C4A (C4a) (Complement Fragment C4a (C4a))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp C4A est non-conjugé

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Fonction: Mouse anti-Human C4d Antibody Complement 4d [Sodium Azide Free]

Specificité: Intracytoplasmic vacuoles of endothelial cells, Secreted

Purification: Human protein was used as the immunogen for this C4d antibody.

Immunogène: Human protein was used as the immunogen for this C4d antibody.

Information d'application

Indications d'application: IF: 1:50-1:100
IHC (FFPE): 1:200-1:400 for 30 minutes at RT (1)
Prediluted format: incubate for 30 min at RT (2),ELISA: 1-2 μg/mL, order the BSA-free format

Restrictions: For Research Use only

Stockage

Buffer: In 1X PBS ( pH 7.4), BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C

Stockage commentaire: 2-8°C

Détails sur C4A

Antigène: C4A (C4a) (Complement Fragment C4a (C4a))

Autre désignation: Complement C4-A (C4a Produits)

Synonymes: anticorps C4, anticorps C4A2, anticorps C4A3, anticorps C4A4, anticorps C4A6, anticorps C4AD, anticorps C4S, anticorps CO4, anticorps CPAMD2, anticorps RG, anticorps Slp, anticorps C4-1, anticorps C4b, anticorps complement C4A (Rodgers blood group), anticorps complement component 4A (Rodgers blood group), anticorps C4A, anticorps C4a

Sujet:

Target Description: This antibody is specific to Complement 4d (C4d) and it reacts with the secreted as well as cell-bound protein. C4d is a degradation product of the activated complement factor C4b. Complement 4b is typically activated by binding of antibodies to specific target molecules. Following activation and degradation of the C4 Molecule, thio-ester groups are exposed, which allow transient, covalent binding of the degradation product C4d to endothelial cell surfaces and extracellular matrix components of vascular basement membranes near the sites of C4 activation. The presence of C4d in peritubular capillaries is a key indicator for acute humoral (i.e. antibody-mediated) rejection of kidney, heart, pancreas and lung allografts. As an established marker of antibody-mediated acute renal allograft rejection and its proclivity for endothelium, this component can be detected in peritubular capillaries in chronic renal allograft rejection as well as hyperacute rejection, acute vascular rejection, acute cellular rejection, and borderline rejection. C4d has been shown to be a significant predictor of transplant kidney graft survival. C4d antibody, combined with antibody to C3d, can be utilized as a tool for diagnosis of allograft rejection that may warrant a prompt and aggressive anti-rejection treatment.

Gene Symbol: C4A///CO4///CPAMD2///C4B///CO4///CPAMD3///C4B_2

ID gène: 720

UniProt: P0C0L4, P0C0L5

Pathways: Système du Complément