SUMO3 anticorps

N° du produit ABIN6297569

L’anticorps Souris Monoclonal anti-SUMO3 a été validé pour IHC. Il convient pour détecter SUMO3 dans des échantillons de Humain.

Aperçu rapide pour SUMO3 anticorps (ABIN6297569)

Antigène: SUMO3 (Small Ubiquitin Related Modifier 3 (SUMO3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SUMO3 est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-SUMO3 anticorps

Fonction: Mouse anti-Human SUMO2/3 Antibody [IHC only]

Specificité: Predominantly nuclear with some cytoplasmic

Purification: Recombinant human SUMO2 protein was used as the immunogen for this SUMO2/3 antibody.

Immunogène: Recombinant human SUMO2 protein was used as the immunogen for this SUMO2/3 antibody.

Information d'application

Indications d'application: Prediluted format : incubate for 30 min at RT (2)

Restrictions: For Research Use only

Stockage

Buffer: Prediluted in 1X PBS ( pH 7.4) with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Détails sur SUMO3

Antigène: SUMO3 (Small Ubiquitin Related Modifier 3 (SUMO3))

Autre désignation: Small ubiquitin-related modifier 3

Sujet:

Target Description: This antibody reacts with both SUMO2 and SUMO3. The small ubiquitin-related modifier (SUMO) proteins, which include SUMO1, 2 and 3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursors that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2 and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets for a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO1/2/3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO1 utilizes Ubc9 for conjugation to several targets, which include MDM2, p53, PML and RanGap1. SUMO2/3 contribute to a greater percentage of protein modification than does SUMO1 and they can form polymeric chains. In addition, SUMO3 regulates beta-Amyloid generation and may be critical in the onset or progression of Alzheimer 's disease.

Gene Symbol: SUMO3///SMT3A///SMT3H1

ID gène: 6613

UniProt: P55854