ANO1 anticorps

N° du produit ABIN6297578

L’anticorps anti-ANO1 Monoclonal Souris est utilisé pour la détection de ANO1 dans des échantillons de Humain. Il a été validé pour IHC.

Aperçu rapide pour ANO1 anticorps (ABIN6297578)

Antigène: ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ANO1 est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-ANO1 anticorps

Fonction: Mouse anti-Human TMEM16A Antibody (DOG1) [IHC only]

Specificité: Cell Surface and Cytoplasmic

Purification: Recombinant human TMEM16A/DOG1 protein was used as the immunogen for this TMEM16A antibody.

Immunogène: Recombinant human TMEM16A/DOG1 protein was used as the immunogen for this TMEM16A antibody.

Information d'application

Indications d'application: Prediluted format : incubate for 30 min at RT (2)

Restrictions: For Research Use only

Stockage

Buffer: Prediluted in 1X PBS ( pH 7.4) with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Détails sur ANO1

Antigène: ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))

Autre désignation: Anoctamin-1

Sujet:

Target Description: Expression of TMEM16A (DOG1) protein is elevated in the gastrointestinal stromal tumors (GIST 's), c-kit signaling-driven mesenchymal tumors of the GI tract. It is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for TMEM16A has been reported in 97.8 percent of scorable GIST 's, including all c-kit negative GIST 's. Overexpression has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha (PDGFR alpha) mutants that fail to express c-kit antigen. The overall sensitivity of TMEM16A and c-kit in GIST 's is nearly identical: 94.4 % vs. 94.7 %.

Gene Symbol: ANO1///DOG1///ORAOV2///TAOS2///TMEM16A

ID gène: 55107

UniProt: Q5XXA6