Cyclin D2 anticorps

N° du produit ABIN6298006

Cet anticorps Lapin Polyclonal détecte spécifiquement Cyclin D2 dans . Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour Cyclin D2 anticorps (ABIN6298006)

Antigène: Cyclin D2 (CCND2)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cyclin D2 est non-conjugé

Application: Veuillez nous consulter SVP

Détail du produit anti-Cyclin D2 anticorps

Fonction: Rabbit Anti-Cyclin D2 (Ab-280) Antibody,

Information d'application

Restrictions: For Research Use only

Stockage

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C (short-term), -20°C (long-term)

Détails sur Cyclin D2

Antigène: Cyclin D2 (CCND2)

Autre désignation: Cyclin D2

Sujet:

Target Description: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).

Gene Symbol: CCND2

ID gène: 894

UniProt: P30279

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases