BRE anticorps

N° du produit ABIN6298367

Détail du produit anti-BRE anticorps

Antigène: BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BRE est non-conjugé

Application: Veuillez nous consulter SVP

Fonction: Rabbit Anti-BRE Antibody,

Information d'application

Restrictions: For Research Use only

Stockage

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C (short-term), -20°C (long-term)

Détails sur BRE

Antigène: BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))

Autre désignation: BRE (BRE Produits)

Synonymes: anticorps brcc4, anticorps brcc45, anticorps BRE, anticorps LOC100231620, anticorps BRCC4, anticorps BRCC45, anticorps 6030405P19Rik, anticorps AI429776, anticorps B830038C02Rik, anticorps im:7141046, anticorps zgc:110368, anticorps BRISC and BRCA1 A complex member 2, anticorps brain and reproductive organ-expressed (TNFRSF1A modulator), anticorps BRISC and BRCA1 A complex member 2 L homeolog, anticorps babam2, anticorps BABAM2, anticorps Babam2, anticorps BRE, anticorps babam2.L

Sujet:

Target Description: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti- apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A, however these effects may be indirect.

Gene Symbol: BRE

ID gène: 9577

UniProt: Q9NXR7

Pathways: Positive Regulation of Response to DNA Damage Stimulus